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KMID : 0353019670040010027
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Korean Journal of Public Health
1967 Volume.4 No. 1 p.27 ~ p.32
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Studies on the Chemoprophylaxis in Clonorchiasis
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盧忍圭/Loh,In Kyu
林道洙/林漢鐘/朴洪圭/Lim,Do Soo/Rim,Han Jong/Park,Hong Kyu
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Abstract
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In this study, using 26 experimental rabbits, proper doses of Hexachlorophene or 1,4-Bis-trichloromethylbenzol ere administered to the rabbits from 1st day of the infection with 500 metacercariae of Clonorchis sinensis. The larvicidal effects of the drugs were judged by the results of examination of Clonorchis eggs in feces and detection status of the adult worms from the liver at autopsy.
And the following results were obtained.
1) In the control group, the detection rate of adult worm was 42.4%.
2) In the group of 10 times administration of Hexachlorophene 40mg(20mg/kg dody weight) in every day dose from 1st day of Clonorchis infection, there was no good larvicidal effect observed and the detection rate of adult worm was 19.0%.
3) In the group of 1,4-Bis-trichloromethylbenzol administration from 1st day of Clonorchis infection, there were no obvious larvicidal effects observed, and the detection rates of adult worm were 46.6%, 29.6% and 43.8% respectively in each of 10 times administration of the drug 100mg(50mg/kg body weight) in every day dose, 5 time administration of the drug 200mg(100mg/kg) in every day dose and 3 times administration of the drug 600mg(300mg/kg) in every other day dose.
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